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literature suggests that concomitant use of ppis with methotrexate primarily at high dose may elevate and prolong serum levels of methotrexate and or its metabolite, possibly leading to methotrexate toxicities.
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a major sle flare was defined as the occurrence of any one of the following due to manifestations of active sle treatment with hdcc or initiation or increase in treatment with other immunosuppressive agents, including azathioprine, mycophenolate mofetil, methotrexate, cyclosporin and leflunomide; or hospitalization or death.
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methotrexate causes the body s immune system to be suppressed, so the live virus vaccine may actually cause illness instead of an immune response.
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